کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5627798 1406355 2017 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Aberrant temporal behavior of mismatch negativity generators in schizophrenia patients and subjects at clinical high risk for psychosis
ترجمه فارسی عنوان
رفتار زمانبندی غیرمستقیم ژنراتورهای منفی ناسازگاری در بیماران مبتلا به اسکیزوفرنیا و افرادی که در معرض خطر بالای بالینی روانپزشکی قرار دارند
کلمات کلیدی
بالینی بالینی برای روانپریشی، تراکم منبع کنونی، سندرم قطع ارتباط، منفی بودن ناسازگاری، جنون جوانی،
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی عصب شناسی
چکیده انگلیسی


- Schizophrenia patients and clinical high risk subjects show decreased mismatch negativity (MMN) strength in frontal and temporal cortices.
- Disconnection between MMN-related brain regions exists even prior to psychosis onset.
- Aberrant MMN generator activity might be related to schizophrenia pathophysiology.

ObjectiveAlthough disconnection syndrome has been considered a core pathophysiologic mechanism of schizophrenia, little is known about the temporal behavior of mismatch negativity (MMN) generators in individuals with schizophrenia or clinical high risk (CHR) for psychosis.MethodsMMN was assessed in 29 schizophrenia patients, 40 CHR subjects, and 47 healthy controls (HCs). Individual realistic head models and the minimum L2 norm algorithm were used to generate a current source density (CSD) model of MMN. The strength and time course of MMN CSD activity were calculated separately for the frontal and temporal cortices and were compared across brain regions and groups.ResultsSchizophrenia patients and CHR subjects displayed lower MMN CSD strength than HCs in both the temporal and frontal cortices. We found a significant time delay in MMN generator activity in the frontal cortex relative to that in the temporal cortex in HCs. However, the sequential temporo-frontal activities of MMN generators were disrupted in both the schizophrenia and CHR groups.ConclusionsImpairments and altered temporal behavior of MMN multiple generators were observed even in individuals at risk for psychosis.SignificanceThese findings suggest that aberrant MMN generator activity might be helpful in revealing the pathophysiology of schizophrenia.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Clinical Neurophysiology - Volume 128, Issue 2, February 2017, Pages 331-339
نویسندگان
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