کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5628586 1579890 2017 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Changes in the interictal and early postictal diffusion and perfusion magnetic resonance parameters in familial spontaneous epileptic cats
ترجمه فارسی عنوان
تغییرات در توزیع زودهنگام و زایمان زودرس و پارامترهای رزونانس مغناطیسی در گربه های صرع خودبخودی خانوادگی
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی عصب شناسی
چکیده انگلیسی


- FSECs had interictal hypoperfusion in the hippocampus.
- The hippocampus in FSECs showed postictal hypodiffusion and hyperperfusion.
- In FSECs, the rMTT of the postictal amygdala was higher than the interictal.
- DWI and PWI could be useful tools for detecting the epileptogenic zone.

ObjectiveThe familial spontaneous epileptic cat (FSEC) is thought to be a good genetic model of mesial temporal lobe epilepsy. In the current study, cerebral diffusion and perfusion magnetic resonance imaging (MRI) were used to confirm the functional deficit zone in the FSEC and evaluate the effect of a single seizure on different brain regions.MethodsSix FSECs and six healthy control cats were used in this study. MRI was performed in the interictal state (resting state for control) and postictal state immediately after the vestibular stimulation-induced generalized epileptic seizure (control cats received the same stimulation as the FSECs). The apparent diffusion coefficient (ADC), fractional anisotropy and perfusion parameters (i.e., relative regional cerebral blood volume (rCBV), relative regional cerebral blood flow (rCBF), and relative regional mean transit time (rMTT)) were measured in the hippocampus, amygdala, thalamus, and gray and white matter.ResultsIn the interictal state, the rCBV and rMTT in the hippocampus was significantly decreased in FSECs, compared to the control. In the postictal state, FSECs had a significantly decreased ADC and an increased rCBV, rCBF, and rMTT in the hippocampus, and an increased rMTT in the amygdala, compared to the interictal state.ConclusionThis study showed that FSECs had interictal hypoperfusion in the hippocampus, and postictal hypodiffusion and hyperperfusion in the hippocampus and/or amygdala. These findings suggested that the hippocampus and/or amygdala act as the functional deficit and expanded seizure-onset zones in FSECs.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Epilepsy Research - Volume 133, July 2017, Pages 76-82
نویسندگان
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