کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5628798 1579999 2017 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Original articleClonidine adhesive patch for the treatment of tic disorders: A systematic review and meta-analysis
ترجمه فارسی عنوان
مقاله اصلی پچ چسب کلونیدین برای درمان اختلالات تیک: بررسی منظم و متاآنالیز
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب تکاملی
چکیده انگلیسی


- The results of our study suggested that clonidine adhesive patch may be as effective as haloperidol or tiapride for tic disorders.
- The most common AEs of clonidine adhesive patch were rash (8.9%), lightheadedness (8.0%), dry mouth (4.0%). The AEs of clonidine adhesive patch were slight.
- The clonidine adhesive patch appears to be a promising therapy for children with TDs, and further well-conducted RCTs are required to confirm this conclusion.

ObjectiveThe aim of this study was to evaluate the efficacy and safety of clonidine adhesive patch for tic disorders (TDs).MethodsMedline, Embase, Cochrane central register of controlled trials and Chinese databases of CBM, CNKI were searched from inception to 08.2016 for randomized controlled studies (RCTs), open-label control studies of clonidine adhesive patch versus other medications or/and placebo for TDs. The cochrane Handbook for Systematic Reviews of Interventions was used to guide our study.ResultsSix studies involving 1145 participants were included in this study. Among these studies, two study (N = 513 patients) used placebo as a control and four studies (N = 632 patients) used positive drug controls. The results of meta-analysis suggested that clonidine adhesive patch may be as effective as haloperidol or tiapride for TDs. Adverse events (AEs) were reported in all studies, and the most common AEs of clonidine adhesive patch were rash (8.9%), lightheadedness (8.0%), dry mouth (4.0%). The AEs of clonidine adhesive patch were slight.ConclusionThese data provide moderate quality evidence that clonidine adhesive patch might be an effective and safe treatment option for TDs, and results from further trials are urgently needed to extend the evidence base.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: European Journal of Paediatric Neurology - Volume 21, Issue 4, July 2017, Pages 614-620
نویسندگان
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