کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5628856 | 1579998 | 2017 | 7 صفحه PDF | دانلود رایگان |
- Left-hemispheric stroke until age five years had favorable language outcome.
- Until age two years, right-hemispheric language reorganization was functionally successful.
- After age five years, good recovery with left-hemispheric (peri-lesional) reorganization.
AimTo identify, in a retrospective, observational study, the time window during which successful right-hemispheric language reorganization is possible after left-hemispheric brain damage.Method25 patients (10 females; age 6-41 years; â¥12 months after insult; age at insult 0;3-15;11 years) with acute, language-relevant left-hemispheric insults acquired during childhood and adolescence completed questionnaires for self-assessment of language problems. 12 patients of those reporting no (n = 8) or only moderate (n = 4) language problems participated in language fMRI.ResultsLanguage outcome of lesions occurring before 5 years of age (n = 7) was always favorable, and language was right-lateralized (2 patients: age at lesion < 2 years) or bilateral (3 patients: age at lesion 2-5 years). Following lesions occurring after 5 years of age, language outcome was often unfavorable (11/18 patients: moderate or severe problems), and of the 7 patients without problems, none showed right-hemispheric reorganization (fMRI available in 4).InterpretationThe combination of normal language outcome and right-hemispheric language reorganization after a left-hemispheric lesion sustained after the neonatal period is extremely rare. Functionally sufficient right-hemispheric language was documented in only two patients with lesions acquired before two years of age.
Journal: European Journal of Paediatric Neurology - Volume 21, Issue 5, September 2017, Pages 715-721