کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5630207 | 1580365 | 2017 | 4 صفحه PDF | دانلود رایگان |
- Lysophosphatidylcholine (LPC) activates caspase-1 in microglia.
- Prestimulation with LPS is required for LPC-induced caspase-1 activation.
- LPC-induced caspase-1 activation depends on inflammasomes NLRC4 and NLRP3.
- LPC-induced caspase-1 activation requires activity of the adaptor protein ASC.
Inflammasomes regulate microglial caspase-1 activation and subsequent neuroinflammatory processes in brain pathology. In the present study, we have identified inflammasomes causing caspase-1 activation following stimulation of microglia with lysophosphatidylcholine (LPC), a proinflammatory lipid generated under pathological conditions in the brain. LPC-induced caspase-1 activation in microglia was found to depend on LPS prestimulation, inflammasome NLRP3 and adaptor molecule ASC. Furthermore, knockdown of inflammasome NLRC4 inhibited LPC-stimulated caspase-1 activity in microglia, suggesting the requirement of two inflammasomes for optimal caspase-1 activity.
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Journal: Journal of Neuroimmunology - Volume 310, 15 September 2017, Pages 107-110