کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5630258 | 1580372 | 2017 | 6 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Lymphocyte subsets as biomarkers of therapeutic response in Fingolimod treated Relapsing Multiple Sclerosis patients Lymphocyte subsets as biomarkers of therapeutic response in Fingolimod treated Relapsing Multiple Sclerosis patients](/preview/png/5630258.png)
- Fingolimod (FTY) induces a re-modulation of the immune system.
- Lymphocytes subsets may predict Multiple Sclerosis disease activity in FTY patients.
- Immune system re-modulation can be a biomarker of FTY therapeutic response.
- ROC curves stratified patients for the risk of relapse at T6 and Gd + lesions at T12.
We investigated, lymphocyte count (LC) and lymphocyte subpopulations (LS) in a real life setting of Fingolimod (FTY) treated Relapsing MS (RMS) patients.Peripheral blood counts with LS, relapses and MRI scans were recorded in a cohort of 119 FTY patients, during one year of treatment. Simple and multivariate logistic regression models, were performed. ROC analysis identified cut-off values of LS predicting a higher risk of relapses and of Gd + lesions.We demonstrated a FTY-induced re-modulation of the immune system, suggesting that LS in RMS FTY treated patients can predict the clinical response to the drug.
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Journal: Journal of Neuroimmunology - Volume 303, 15 February 2017, Pages 75-80