کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5630828 1580849 2017 10 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Complementary contributions of concurrent EEG and fMRI connectivity for predicting structural connectivity
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب شناختی
پیش نمایش صفحه اول مقاله
Complementary contributions of concurrent EEG and fMRI connectivity for predicting structural connectivity
چکیده انگلیسی


- EEG connectivity improves prediction of dMRI from function above fMRI alone.
- Cross-validation shows model improvement with EEG at subject and group levels.
- EEG contributes in a subband-specific way at global δ and local γ levels.
- Contributions are mediated by topological, geometric and intrinsic architecture.

While averaged dynamics of brain function are known to estimate the underlying structure, the exact relationship between large-scale function and structure remains an unsolved issue in network neuroscience. These complex functional dynamics, measured by EEG and fMRI, are thought to arise from a shared underlying structural architecture, which can be measured by diffusion MRI (dMRI). While simulation and data transformation (e.g. graph theory measures) have been proposed to refine the understanding of the underlying function-structure relationship, the potential complementary and/or independent contribution of EEG and fMRI to this relationship is still poorly understood.As such, we explored this relationship by analyzing the function-structure correlation in fourteen healthy subjects with simultaneous resting-state EEG-fMRI and dMRI acquisitions. We show that the combination of EEG and fMRI connectivity better explains dMRI connectivity and that this represents a genuine model improvement over fMRI-only models for both group-averaged connectivity matrices and at the individual level. Furthermore, this model improves the prediction within each resting-state network. The best model fit to underlying structure is mediated by fMRI and EEG-δ connectivity in combination with Euclidean distance and interhemispheric connectivity with more local contributions of EEG-γ at the scale of resting-state networks.This highlights that the factors mediating the relationship between functional and structural metrics of connectivity are context and scale dependent, influenced by topological, geometric and architectural features. It also suggests that fMRI studies employing simultaneous EEG measures may characterize additional and essential parts of the underlying neuronal activity of the resting-state, which might be of special interest for both clinical studies and the investigation of resting-state dynamics.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: NeuroImage - Volume 161, 1 November 2017, Pages 251-260
نویسندگان
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