کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5631134 1580855 2017 17 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
On the importance of modeling fMRI transients when estimating effective connectivity: A dynamic causal modeling study using ASL data
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب شناختی
پیش نمایش صفحه اول مقاله
On the importance of modeling fMRI transients when estimating effective connectivity: A dynamic causal modeling study using ASL data
چکیده انگلیسی


- P-DCM is applied to assess effective connectivity from BOLD and ASL data.
- Effective connectivity estimates depend on accurately modeling response transients.
- Physiologically informed dynamic causal model (P-DCM) is extended to ASL fMRI data.
- Statistical superiority and inter-subject consistency of P-DCM over other DCMs.
- ASL-DCM increases specificity of connectivity estimates compared to BOLD-DCM.

Effective connectivity is commonly assessed using blood oxygenation level-dependent (BOLD) signals. In (Havlicek et al., 2015), we presented a novel, physiologically informed dynamic causal model (P-DCM) that extends current generative models. We demonstrated the improvements afforded by P-DCM in terms of the ability to model commonly observed neuronal and vascular transients in single regions. Here, we assess the ability of the novel and previous DCM variants to estimate effective connectivity among a network of five ROIs driven by a visuo-motor task. We demonstrate that connectivity estimates depend sensitively on the DCM used, due to differences in the modeling of hemodynamic response transients; such as the post-stimulus undershoot or adaptation during stimulation. In addition, using a novel DCM for arterial spin labeling (ASL) fMRI that measures BOLD and CBF signals simultaneously, we confirmed our findings (by using the BOLD data alone and in conjunction with CBF). We show that P-DCM provides better estimates of effective connectivity, regardless of whether it is applied to BOLD data alone or to ASL time-series, and that all new aspects of P-DCM (i.e. neuronal, neurovascular, hemodynamic components) constitute an improvement compared to those in the previous DCM variants. In summary, (i) accurate modeling of fMRI response transients is crucial to obtain valid effective connectivity estimates and (ii) any additional hemodynamic data, such as provided by ASL, increases the ability to disambiguate neuronal and vascular effects present in the BOLD signal.

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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: NeuroImage - Volume 155, 15 July 2017, Pages 217-233
نویسندگان
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