کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5631161 1580855 2017 12 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Optimising experimental design for MEG resting state functional connectivity measurement
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب شناختی
پیش نمایش صفحه اول مقاله
Optimising experimental design for MEG resting state functional connectivity measurement
چکیده انگلیسی


- We test the effect of recording duration and coregistration error on MEG connectivity.
- Headcasts improve repeatability of beamformer reconstruction and connectivity.
- Data duration has the biggest effect on reproducibility of connectivity.
- Short recordings are inefficient at capturing the canonical MEG network.

The study of functional connectivity using magnetoencephalography (MEG) is an expanding area of neuroimaging, and adds an extra dimension to the more common assessments made using fMRI. The importance of such metrics is growing, with recent demonstrations of their utility in clinical research, however previous reports suggest that whilst group level resting state connectivity is robust, single session recordings lack repeatability. Such robustness is critical if MEG measures in individual subjects are to prove clinically valuable. In the present paper, we test how practical aspects of experimental design affect the intra-subject repeatability of MEG findings; specifically we assess the effect of co-registration method and data recording duration. We show that the use of a foam head-cast, which is known to improve co-registration accuracy, increased significantly the between session repeatability of both beamformer reconstruction and connectivity estimation. We also show that recording duration is a critical parameter, with large improvements in repeatability apparent when using ten minute, compared to five minute recordings. Further analyses suggest that the origin of this latter effect is not underpinned by technical aspects of source reconstruction, but rather by a genuine effect of brain state; short recordings are simply inefficient at capturing the canonical MEG network in a single subject. Our results provide important insights on experimental design and will prove valuable for future MEG connectivity studies.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: NeuroImage - Volume 155, 15 July 2017, Pages 565-576
نویسندگان
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