کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5631232 1580861 2017 11 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Mapping the critical gestational age at birth that alters brain development in preterm-born infants using multi-modal MRI
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب شناختی
پیش نمایش صفحه اول مقاله
Mapping the critical gestational age at birth that alters brain development in preterm-born infants using multi-modal MRI
چکیده انگلیسی


- Diffusion tensor and T2-mapping MRI was measured from preterm and term-born infants.
- Change point analysis detects critical gestational age at birth (GAB) in 126 brain regions.
- Change-points maps revealed spatiotemporal order of structural development.
- GAB-dependent MRI change reflected brain prematurity and postnatal development.

Preterm birth adversely affects postnatal brain development. In order to investigate the critical gestational age at birth (GAB) that alters the developmental trajectory of gray and white matter structures in the brain, we investigated diffusion tensor and quantitative T2 mapping data in 43 term-born and 43 preterm-born infants. A novel multivariate linear model-the change point model, was applied to detect change points in fractional anisotropy, mean diffusivity, and T2 relaxation time. Change points captured the “critical” GAB value associated with a change in the linear relation between GAB and MRI measures. The analysis was performed in 126 regions across the whole brain using an atlas-based image quantification approach to investigate the spatial pattern of the critical GAB. Our results demonstrate that the critical GABs are region- and modality-specific, generally following a central-to-peripheral and bottom-to-top order of structural development. This study may offer unique insights into the postnatal neurological development associated with differential degrees of preterm birth.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: NeuroImage - Volume 149, 1 April 2017, Pages 33-43
نویسندگان
, , , , , , ,