کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5631301 1580862 2017 13 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Optimal trajectories of brain state transitions
ترجمه فارسی عنوان
مسیرهای بهینه انتقال جابجایی مغز
کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب شناختی
چکیده انگلیسی


- We use network control theory to model mechanisms of brain state transitions.
- Attention and executive areas are poised to affect an array of state transitions.
- Patients with mild traumatic injury display less specificity in control processes.

The complexity of neural dynamics stems in part from the complexity of the underlying anatomy. Yet how white matter structure constrains how the brain transitions from one cognitive state to another remains unknown. Here we address this question by drawing on recent advances in network control theory to model the underlying mechanisms of brain state transitions as elicited by the collective control of region sets. We find that previously identified attention and executive control systems are poised to affect a broad array of state transitions that cannot easily be classified by traditional engineering-based notions of control. This theoretical versatility comes with a vulnerability to injury. In patients with mild traumatic brain injury, we observe a loss of specificity in putative control processes, suggesting greater susceptibility to neurophysiological noise. These results offer fundamental insights into the mechanisms driving brain state transitions in healthy cognition and their alteration following injury.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: NeuroImage - Volume 148, 1 March 2017, Pages 305-317
نویسندگان
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