Short- and long-term outcomes of small auto- and cryopreserved allograft skin grafting in those with >60%TBSA deep burn wounds

- Small auto- and cryopreserved allograft skin grafting expands the utilization ratio of available donor sites, and offers a high graft survival rate.
- Persistence of dermis in the allograft as the dermal substitute may reduce scar formation.
- This technique provides an option for more rapid repair of large-area deep burn wounds.

BackgroundThe shortage of autologous skin sources not only adds difficulty to the repair of extremely large-area deep burn wounds but affects the healing quality. The aim of the present study is to explore an ideal method for repairing large-areas burn wounds with low scar formation.MethodsBetween 2002 and 2014, we used grafting of small auto- and cryopreserved allo-skin to repair large-area residual burn wounds in wounds after 21 days 21 patients, and after early excision in 17 patients. The wound healing rate and quality were observed.ResultsThe skin expansion rate was 1:9-1:16, and the mean area of wounds repaired after three weeks was 64.8 ± 7.3%TBSA, the wound healing rate was 91.8 ± 3.7%. The mean area of the early excision group was 65.9 ± 9.8 TBSA, where the healing rate was 94.5 ± 5.6%. After small auto- and cryopreserved allograft skin grafting, the epidermis of the auto-skin gradually replaced the allo-epidermis, and the allo-dermis persisted for a prolonged period. The dermal collagen fibers at the allo-skin grafting sites were well arranged. At 1-2-year follow-up, observation showed that the Vancouver Scar Scale total score was 4·304 ± 2·363, and we did not discern significant contracture and dysfunction in the large joints of the four extremities.ConclusionsSmall auto- and cryopreserved allograft skin grafting of small auto- and allo-skin not only raised the graft expansion rate but offers a stable wound healing rate. This new technique may provide an option for repair of large-area deep burn wounds.