کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5639177 1584103 2017 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Prognostic significance of extracapsular spread of lymph node metastasis from oral squamous cell carcinoma in the clinically negative neck
ترجمه فارسی عنوان
اهمیت پیش آگهی گسترش غده فوق کلیه متاستاز گره لنفاوی از کارسینوم سلول سنگفرشی دهانی در گردن بالینی منفی
کلمات کلیدی
سرطان دهان، متاستاز گره لنفاوی، گسترش فوق العاده کپسول، عود، بقای،
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی دندانپزشکی، جراحی دهان و پزشکی
چکیده انگلیسی

The presence of extracapsular spread (ECS) in patients with oral squamous cell carcinoma (OSCC) indicates a poor prognosis and is associated with a higher risk of regional recurrence and distant metastasis. The aim of this study was to analyse this important feature of cervical lymph nodes in the clinically node-negative setting. The study included 61 patients with clinically T1-T3N0 OSCC who underwent primary surgical treatment; 52 were male and nine were female, and their median age was 57 years. The 5-year disease-free survival, disease-specific survival, and overall survival rates were 30.6%, 28.3%, and 14.3%, respectively, in the ECS group compared to 61.9%, 61.9%, and 48.2%, respectively, in the pN+/ECS-negative group and 76.7%, 81.9%, and 47.0%, respectively, in the pN0 group. The differences between the survival curves were highly significant (P = 0.023, P = 0.003, and P = 0.029, respectively). The incidence of local (50% vs. 14.9%, P = 0.011) and regional (28.6% vs. 2.1%, P = 0.008) recurrence was significantly greater in the ECS group compared to the other subgroups of patients. Furthermore, the time to recurrence was significantly shorter in the ECS subjects. The presence of ECS in patients with oral cancer indicates a poor prognosis. ECS is a frequent feature in clinically node-negative settings and may be more common in smaller lymph nodes than is generally appreciated.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: International Journal of Oral and Maxillofacial Surgery - Volume 46, Issue 6, June 2017, Pages 669-675
نویسندگان
, , , , ,