Carcinoma Ex Pleomorphic Adenoma: Is It a High-Grade Malignancy?

Frankly invasive CXPA was a high-grade malignancy with an unfavorable prognosis. Elective neck dissection should be performed in cases of frankly invasive CXPA that originate in the submandibular gland. Patients with minimally invasive and noninvasive CXPA should be followed closely after primary treatment because regional or distant metastasis can occur.