کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5655594 1407322 2017 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Fecal calprotectin as an alternative to ulcerative colitis endoscopic index of severity to predict the response to corticosteroids of acute severe ulcerative colitis: A prospective observational study
ترجمه فارسی عنوان
کالپروتکتین مدفوع به عنوان جایگزینی برای شاخص اندوسکوپی کولیت اولسراتیو شدت برای پیش بینی پاسخ به کورتیکواستروئیدهای کولیت اولسراتیو حاد حاد: یک مطالعه مشاهدهی آینده
کلمات کلیدی
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی غدد درون ریز، دیابت و متابولیسم
چکیده انگلیسی

BackgroundFecal calprotectin (FC) might be an alternative to ulcerative colitis endoscopic index of severity (UCEIS) to predict the response to corticosteroids (CS) in acute severe colitis (ASC).MethodsOne hundred and seventeen ASC patients were prospectively enrolled. Demographic, clinical, laboratory and sigmoidoscopic data were documented. Multivariate and ROC analyses were performed to identify risk factors for non-response to CS, and the predictive accuracy of possible predictors was assessed.ResultsTotally, 39 (33.33%) patients failed intravenous CS therapy. CS responders among mild (UCEIS 3-4), moderate (UCEIS 5-6) and severe (UCEIS 7-8) groups were 40/44 (90.91%) vs. 36/55 (65.45%) vs. 2/18 (11.11%) (p < 0.001). UCEIS (OR = 5.08; 95% CI, 1.93-8.66; p < 0.001) and FC (OR = 2.56; 95% CI, 1.17-3.55; p = 0.022) were found to be independent risk factors for CS non-responders. Compared with C-reactive protein, platelet, hemoglobin and albumin, baseline FC had the strongest correlation with UCEIS (r = 0.701, p < 0.001). ROC analysis of UCEIS and baseline FC in predicting CS non-response showed an AUC of 0.85 and 0.76 respectively.ConclusionsBaseline FC levels correlated significantly with UCEIS in ASC, and both were useful in predicting short-term outcome of CS treatment. Baseline FC levels could be used as an alternative of UCEIS to guide the decision of early salvage therapy or colectomy and reduce the adverse effects of long-term futile CS usage.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Digestive and Liver Disease - Volume 49, Issue 9, September 2017, Pages 984-990
نویسندگان
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