کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5658410 1407433 2017 19 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Long Noncoding RNAs in the Pathogenesis of Barrett's Esophagus and Esophageal Carcinoma
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی بیماری‌های گوارشی
پیش نمایش صفحه اول مقاله
Long Noncoding RNAs in the Pathogenesis of Barrett's Esophagus and Esophageal Carcinoma
چکیده انگلیسی
For many years, only a small fraction of the human genome was believed to regulate cell function and development. This protein-coding portion composed only 1% to 2% of 3 billion human DNA base pairs-the remaining sequence was classified as junk DNA. Subsequent research has revealed that most of the genome is transcribed into a broad array of noncoding RNAs, ranging in size from microRNA (20-23 nucleotides) to long noncoding RNA (lncRNA, more than 200 nucleotides). These noncoding RNA classes have been shown to use diverse molecular mechanisms to control gene expression and organ system development. As anticipated, alterations in this large control system can contribute to disease pathogenesis and carcinogenesis. We review the involvement of noncoding RNAs, lncRNAs in particular, in development of Barrett's esophagus and esophageal carcinoma.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Gastroenterology - Volume 153, Issue 1, July 2017, Pages 27-34
نویسندگان
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