کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5659378 1407462 2017 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Clinical outcomes of non-curative endoscopic submucosal dissection with negative resected margins for gastric cancer
ترجمه فارسی عنوان
نتیجه بالینی تشخیص غدد درون ریز آندوسکوپیک غیر دارویی با حاشیه منفی برداشته شده برای سرطان معده
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی بیماری‌های گوارشی
چکیده انگلیسی

Background and AimsThere has been little information about the long-term outcomes of patients with early gastric cancer (EGC) treated by non-curative endoscopic submucosal dissection (ESD) with negative resected margins (R0 resection). We aimed to compare the clinical outcomes of non-curative ESD with R0 resection between patients who underwent additional gastrectomy and those who did not.MethodsAmong EGC patients treated by ESD from 2002 to 2010, 66 patients were treated by non-curative ESD with R0 resection. Patients received either additional gastrectomy (group A, n = 45) or were followed up without gastrectomy (group B, n = 21). The clinicopathologic findings and the subsequent clinical course were compared between the 2 groups.ResultsPatients in group A were younger than those in group B (68.0 vs 71.0 years, P = .006). The follow-up period was longer in group A than in group B (7.8 vs 5.9 years, P = .011). The percentage of patients who died of any cause was not statistically lower in group A than in group B (13.3% vs 33.3%, P = .06). Although the overall survival rate was higher in group A than in group B (93.3% vs 76.2%, P = .028), disease-specific survival rates did not differ between the 2 groups (97.8% vs 100%, P = .495). A Cox proportional hazards model showed that gastrectomy was not an independent factor associated with overall survival.ConclusionsCareful follow-up may be an alternative strategy to gastrectomy for a subgroup of patients treated by non-curative ESD with R0 resection.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Gastrointestinal Endoscopy - Volume 85, Issue 6, June 2017, Pages 1218-1224
نویسندگان
, , , , , , , , , , , , , , , , , , , ,