کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5662863 1590568 2017 16 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Reproduction numbers of infectious disease models
ترجمه فارسی عنوان
تعداد نسخه های بیماری های عفونی
کلمات کلیدی
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی انفورماتیک سلامت
چکیده انگلیسی

This primer article focuses on the basic reproduction number, ℛ0, for infectious diseases, and other reproduction numbers related to ℛ0 that are useful in guiding control strategies. Beginning with a simple population model, the concept is developed for a threshold value of ℛ0 determining whether or not the disease dies out. The next generation matrix method of calculating ℛ0 in a compartmental model is described and illustrated. To address control strategies, type and target reproduction numbers are defined, as well as sensitivity and elasticity indices. These theoretical ideas are then applied to models that are formulated for West Nile virus in birds (a vector-borne disease), cholera in humans (a disease with two transmission pathways), anthrax in animals (a disease that can be spread by dead carcasses and spores), and Zika in humans (spread by mosquitoes and sexual contacts). Some parameter values from literature data are used to illustrate the results. Finally, references for other ways to calculate ℛ0 are given. These are useful for more complicated models that, for example, take account of variations in environmental fluctuation or stochasticity.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Infectious Disease Modelling - Volume 2, Issue 3, August 2017, Pages 288-303
نویسندگان
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