Activity of telavancin against Gram-positive pathogens isolated from bone and joint infections in North American, Latin American, European and Asia-Pacific nations

- A total of 967 Gram-positive isolates were included, deemed to cause bone and joint infections among patients hospitalized in medical centers worldwide.
- S. aureus (642; 66.4%) and coagulase-negative staphylococci (117; 12.1%) were the dominant pathogens, followed by streptococci (143; 14.8%) and enterococci (65; 6.7%).
- All indicated S. aureus, streptococci and vancomycin-susceptible E. faecalis isolates were susceptible to telavancin.
- Telavancin also inhibited all coagulase-negative staphylococci at ≤0.06 μg/mL.

Telavancin was tested against a worldwide collection of Gram-positive pathogens (967) isolated from bone and joint infections (BJI). Most BJI isolates were from the United States (US) (49.9%) followed by Europe (26.4%), Latin America (LATAM; 14.4%), and Asia-Pacific (APAC; 9.3%). Organisms were tested by broth microdilution susceptibility methods. S. aureus (66.4%; range of 48.9% in APAC to 71.2% in LATAM) was the most common pathogen and had a 35.7% methicillin resistance (MRSA) rate and telavancin MIC50/90 of 0.03/0.06 μg/mL (100% susceptible). MRSA isolates that were daptomycin resistant (0.2%) were telavancin susceptible. CoNS (12.1% of BJI) had telavancin MIC50/90 at 0.06/0.06 μg/mL, and 13.7% were teicoplanin resistant. Enterococci had telavancin MIC50/90 at 0.12/0.25 μg/mL, but telavancin inhibited vancomycin-susceptible isolates at ≤0.25 μg/mL. All streptococci were telavancin susceptible (MIC90, 0.03-0.06 μg/mL). The in vitro results presented here warrant further investigations to access the role of telavancin for BJI/osteomyelitis treatment caused by Gram-positive cocci.