کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5665870 | 1407775 | 2017 | 4 صفحه PDF | دانلود رایگان |
- HCV-Ag assay presents a strong correlation compared with RT-PCR.
- HCV-Ag assay correctly classified all patients with sustained virological response.
- HCV-Ag assay correctly detected all patients with treatment failures.
- Viral load curves were almost the same both determined by RT-PCR and HCV-Ag.
- HCV-Ag assay showed to be a reliable technique to monitor DAA treatments.
We evaluated the diagnostic usefulness of an HCV core antigen (HCV-Ag) assay in HCV-infected patients undergoing treatment with direct-acting antivirals. We analyzed 103 samples from 28 patients. Compared with RT-PCR, sensitivity was 96.2% and specificity was 100%. The correlation between techniques was excellent (Pearson coefficient: 0.871). HCV-Ag proved to be useful in patients with sustained viral response and in patients who experienced treatment failures.
Journal: Diagnostic Microbiology and Infectious Disease - Volume 87, Issue 3, March 2017, Pages 243-246