کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5666405 1407799 2016 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
CTLA-4 and IL-6 gene polymorphisms: Risk factors for recurrent pregnancy loss
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی ایمونولوژی
پیش نمایش صفحه اول مقاله
CTLA-4 and IL-6 gene polymorphisms: Risk factors for recurrent pregnancy loss
چکیده انگلیسی

The purpose of the present study was to evaluate the possible association between CTLA-4 +49A/G and IL-6 −634C/G polymorphisms, and the risk of recurrent pregnancy loss (RPL). 240 women (120 healthy controls and 120 with RPL) were enrolled in this case-control study. Genotyping was performed using a PCR-RFLP technique. In the case of polymorphic CTLA-4 +49A/G, the wild type allele G was associated with a decreased risk of RPL (OR: 0.42, 95%CI: 0.25-0.69, p = 0.001). As to IL-6 −634C/G polymorphism, a highly significant difference was observed, and those women who carry at least one mutant G allele presented a probability of developing RPL about 5 times greater than controls (OR: 5.1, 95%CI: 1.04-25.3, p = 0.04). The results indicate that polymorphisms of CTLA-4 and IL-6 genes may influence the risk of developing RPL among Iranian women, suggesting that more research on the immunogenetics of pregnancy should be conducted to confirm our results, and to declare the exact roles of studied molecules in RPL pathogenesis.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Human Immunology - Volume 77, Issue 12, December 2016, Pages 1271-1274
نویسندگان
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