کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5667112 | 1591745 | 2017 | 6 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Activity of moxifloxacin and linezolid against Mycobacterium tuberculosis in combination with potentiator drugs verapamil, timcodar, colistin and SQ109 Activity of moxifloxacin and linezolid against Mycobacterium tuberculosis in combination with potentiator drugs verapamil, timcodar, colistin and SQ109](/preview/png/5667112.png)
- SQ109 as single drug showed strong bactericidal activity against Mycobacterium tuberculosis.
- Verapamil, timcodar and SQ109 showed no added value to the moxifloxacinâ+âlinezolid combination.
- Colistin potentiated the moxifloxacinâ+âlinezolid combination.
Current treatment for tuberculosis (TB) is complicated by the emergence of multidrug resistant TB (MDR-TB). As a result, there is an urgent need for new powerful anti-TB regimens and novel strategies. In this study, we aimed to potentiate a moxifloxacinâ+âlinezolid backbone as treatment for MDR-TB with the efflux pump inhibitors verapamil and timcodar as well as with drugs that act on mycobacterial cell wall stability such as colistin and SQ109. Using a time-kill kinetics assay, the activities of moxifloxacin, linezolid, verapamil, timcodar, colistin and SQ109 as single drugs against Mycobacterium tuberculosis were evaluated. In addition, the activity of the moxifloxacinâ+âlinezolid backbone in combination with one of the potentiator drugs was assessed. As little as 0.125âmg/L moxifloxacin achieved 99% killing of M. tuberculosis after 6 days of exposure. Linezolid showed moderate killing but 99% killing was not achieved. Verapamil, timcodar and colistin only resulted in killing with the highest concentrations tested but 99% killing was not achieved. SQ109 resulted in complete elimination after 1 day of exposure to 256âmg/L and in 99% elimination after 6 days of exposure to 1âmg/L. Furthermore, colistin added to the moxifloxacinâ+âlinezolid backbone resulted in increased elimination, whereas verapamil, timcodar and SQ109 showed no added value to the backbone. This finding that colistin potentiates the activity of the moxifloxacinâ+âlinezolid backbone against M. tuberculosis suggests its potential role in further studies on the applicability of a moxifloxacinâ+âlinezolid treatment of MDR-TB.
Journal: International Journal of Antimicrobial Agents - Volume 49, Issue 3, March 2017, Pages 302-307