کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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5667320 | 1592036 | 2017 | 8 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Pneumocystis pneumonia in patients with inflammatory or autoimmune diseases: Usefulness of lymphocyte subtyping Pneumocystis pneumonia in patients with inflammatory or autoimmune diseases: Usefulness of lymphocyte subtyping](/preview/png/5667320.png)
- Lymphocyte subtyping is useful for predicting Pneumocystis jirovecii pneumonia (PCP) and related mortality in non-HIV patients.
- A CD3+ cell count <625Â ÃÂ 106/l was found to be an independent predictor and the strongest predictor of PCP.
- 90% of patients with PCP had a CD3+ cell count <750Â ÃÂ 106/l.
- Low CD8+ was found to be an independent predictor and the strongest predictor of mortality in PCP patients.
SummaryObjectivesNo consensus currently exists on the indications for Pneumocystis jirovecii prophylaxis in patients with inflammatory or autoimmune diseases. The main objective was to identify biomarkers associated with P. jirovecii pneumonia (PCP) in this population.MethodsA retrospective study was carried out at Beijing Union Medical College Hospital (2003-2014). All patients with an inflammatory or autoimmune disease presenting with acute onset of fever and respiratory symptoms were included.ResultsA total of 123 patients were included, of whom 42% had confirmed PCP, 18% had possible PCP, and 40% were negative for PCP. Immunosuppressive conditions consisted mostly of diffuse connective tissue disease (50%) and primary nephropathy (20%). Immunosuppressive therapies consisted of corticosteroids (95%) with concomitant non-steroidal drugs (80%). Independent predictors of PCP were a CD3+ cell count <625Â ÃÂ 106/l, serum albumin <28Â g/l, and PaO2/FiO2 <210. Furthermore, 90% of patients with PCP had a CD3+ cell count <750Â ÃÂ 106/l. Independent predictors of mortality were a CD8+ cell count <160Â ÃÂ 106/l and a PaO2/FiO2 <160.ConclusionsIn patients with inflammatory and autoimmune conditions receiving immunosuppressive therapy, low CD3+ and CD8+ cell counts were strongly associated with PCP and its mortality. These results suggest that lymphocyte subtyping is a very useful tool to optimize the selection of patients needing prophylaxis.
Journal: International Journal of Infectious Diseases - Volume 57, April 2017, Pages 108-115