کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5667605 1407863 2017 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Development of temporomandibular joint arthritis: The use of animal models
ترجمه فارسی عنوان
توسعه آرتروز مفصل گردن: استفاده از مدل های حیوانی
کلمات کلیدی
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی ایمونولوژی، آلرژی و روماتولوژی
چکیده انگلیسی

Osteoarthritis is the most common joint disease affecting roughly one sixth of the human population. It is also the most common arthritis affecting the temporomandibular joint, often leading to severe pain and the inability to masticate. Animal models are essential to investigate the disease in part because they lend themselves to genetic manipulation and various treatments and also because of the lack of availability of human specimens from various stages of the disease. The wide range of osteoarthritis models alone are a proof of its multifactorial origin. Manipulation of collagen, cytokine, matrix metalloproteinase and small leucine-rich repeat proteoglycan genes can all have an effect on the development and persistence of arthritis. Surgical models also exist, highlighting the importance of normal anatomy and trauma. Here we review the English literature of murine models of temporomandibular joint arthritis with special attention to the genetic and molecular background of osteoarthritis.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Joint Bone Spine - Volume 84, Issue 2, March 2017, Pages 145-151
نویسندگان
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