کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5667747 1407867 2017 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Hyperferritinemia increases the risk of hyperuricemia in HFE-hereditary hemochromatosis
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی ایمونولوژی، آلرژی و روماتولوژی
پیش نمایش صفحه اول مقاله
Hyperferritinemia increases the risk of hyperuricemia in HFE-hereditary hemochromatosis
چکیده انگلیسی

ObjectivesHyperuricemia is becoming increasingly frequent in the population, and is known to be sometimes the cause of gout. The impact of uric acid is still not clearly understood, however. The iron metabolism may interact with the uric acid metabolism. The aim of this study was to examine the relationship between the serum uric acid and serum ferritin levels in a cohort of hemochromatosis patients who were homozygous for the HFE p.Cys282Tyr mutation.Methods738 patients with the HFE gene mutation Cys282Tyr in the homozygous state were included in the study. The variables measured during the initial evaluation were compared in univariate analysis by Student's t test. In multivariate analysis, linear stepwise regression was used.ResultsIn the group of hyperuricemic patients, ferritinemia was significantly higher than in the group of non-hyperuricemic patients (1576.7 ± 1387.4 μg/l vs. 1095.63 ± 1319.24 μg/l, P < 0.005). With multivariate analysis, only ferritin and BMI independently explained the uricemia (R2 = 0.258) after adjustment for age, glycemia and CRP. The correlation between uricemia and log(ferritin) with partial regression correlation coefficients was 0.307 (P < 0.01).ConclusionsThe increase in uricemia is associated with the increase in ferritin in a population of patients who were homozygous for the HFE gene mutation p.Cys282Tyr and this independently of factors commonly associated with hyperuricemia. The increase in uric acid associated with hyperferritinemia, could be a response to the visceral toxicity of excess non-transferrin bound iron linked to oxidative stress via the antioxidant properties of uric acid.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Joint Bone Spine - Volume 84, Issue 3, May 2017, Pages 293-297
نویسندگان
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