کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
56710 | 47092 | 2009 | 6 صفحه PDF | دانلود رایگان |
A green protocol for the synthesis of quinazoline-2,4(1H,3H)-diones from carbon dioxide and 2-aminobenzonitriles using a basic ionic liquid, 1-butyl-3-methyl imidazolium hydroxide ([Bmim]OH) as a catalyst have been reported. The effects of various reaction parameters like catalyst screening, catalyst loading, reaction time, solvent, temperature and pressure on the reaction system were investigated. A wide variety of aromatic aminobenzonitriles and five/six member N-heterocyclic carbonitriles were synthesized using this protocol. All these reaction were carried out under solvent-free condition. The ionic liquid was recovered and reused successfully for the title reaction. 6,7-Dimethoxyquinazoline-2,4(1H,3H)-diones, which is a key intermediates for several drugs (Prazosin, Bunazosin and Doxazosin) was synthesized successfully.
Journal: Catalysis Today - Volume 148, Issues 3–4, 30 November 2009, Pages 355–360