کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5693511 | 1410169 | 2017 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
A clinical perspective on regional nodal irradiation for breast cancer
ترجمه فارسی عنوان
یک چشم انداز بالینی در مورد ترویج گره های منطقه ای برای سرطان پستان
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کلمات کلیدی
NCTSupraclavicular fossaSCVRNIPMRTLRRALNDEORTCSLNIMCRegional nodal irradiation - تابش ناحیه گرهAxillary lymph node dissection - جداسازی گره لنفاوی زیر بغلBreast conserving surgery - جراحی محافظت از پستانPostmastectomy radiotherapy - رادیوتراپی PostmastectomyBCs - روند BCsInternal mammary chain - زنجیره پستان داخلیEuropean Organization for Research and Treatment of Cancer - سازمان اروپایی تحقیقات و درمان سرطانNeoadjuvant chemotherapy - شیمیدرمانی نئوادجوانتLocoregional recurrence - عود محلیPCR - واکنش زنجیرهٔ پلیمرازcomplete pathologic response - پاسخ پاتولوژیک کاملSentinel lymph node - گره لنفاوی Sentinel
موضوعات مرتبط
علوم پزشکی و سلامت
پزشکی و دندانپزشکی
زنان، زایمان و بهداشت زنان
چکیده انگلیسی
The goal of regional treatments in breast cancer should be to eradicate any disease within lymph nodes, avoid regional recurrences, minimize the risk of distant metastases, and improve survival. In addition, regional treatments should focus on reducing potential morbidities and optimizing the long-term quality of life of breast cancer survivors. While data from recent surgical and radiation trials have helped clarify many issues regarding regional treatment, there still remains controversy as to the optimal approach for patients with “intermediate risk” disease. Two large radiation oncology studies (MA.20 and EORTC2292-10925) evaluated whether more extensive lymphatic treatment benefited patients with higher-risk lymph node-negative, or lower risk lymph node-positive disease. A meta-analysis of these two studies suggested that the addition of regional nodal irradiation (RNI) to the level III axillary, supraclavicular and upper internal mammary lymph nodes conferred an improvement in disease free survival and distant metastasis free survival as well as a 1-2% overall survival advantage. However, other studies have suggested that many patients with positive sentinel lymph nodes who are treated with breast conservation including breast irradiation may safely avoid the morbidity and costs of further axillary treatment (whether surgical or radiotherapy-based). In general, patients with 1-3 positive lymph nodes or high-risk, node negative stage II breast cancer represent a diverse population who require individualized, rather than group-based, risk assessment when considering RNI. This article will propose a strategic methodology to assess the modern day breast cancer patient's need for RNI in the setting of changing surgical, radiation, and systemic therapies.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: The Breast - Volume 34, Supplement 1, August 2017, Pages S85-S90
Journal: The Breast - Volume 34, Supplement 1, August 2017, Pages S85-S90
نویسندگان
Amy C. Moreno, Simona F. Shaitelman, Thomas A. Buchholz,