کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5703946 | 1602557 | 2017 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Co-instillation of nano-solid magnesium hydroxide enhances corneal permeability of dissolved timolol
ترجمه فارسی عنوان
ترکیب تزریق هیدروکسید منیزیم نانو به افزایش نفوذپذیری قرنیه تیتولول محلول
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کلمات کلیدی
ABSMTFCMMHNMHMgCl2iOpDDSMRTAUC - AUCBAC - LACBenzalkonium chloride - بنزالکنیم کلریدTimolol - تیمولولTimolol maleate - تیمولول مایناتAbsorbance - جذبDrug delivery systems - سیستم های تحویل داروIntraocular pressure - فشار داخل چشمMethylcellulose - متیل سلولزEquation - معادلهMean residence time - میانگین زمان اقامتNanoparticle - نانوذارتCorneal penetration - نفوذ قرنیهMagnesium hydroxide - هیدروکسید منیزیمMagnesium chloride - کلرید منیزیمGlaucoma - گلوکوم
موضوعات مرتبط
علوم زیستی و بیوفناوری
ایمنی شناسی و میکروب شناسی
ایمونولوژی و میکروب شناسی (عمومی)
چکیده انگلیسی
We prepared magnesium hydroxide (MH) nanoparticles by a bead mill method, and investigated whether the co-instillation of MH nanoparticles improves the low transcorneal penetration of water-soluble drugs, such as the anti-glaucoma eye drug timolol maleate (TM). MH particle size was decreased by the bead mill treatment to a mean particle size of 71Â nm. In addition, the MH nanoparticles were highly stable. Next, we demonstrated the effect of MH nanoparticles on the corneal surface. MH shows only slight solubility in lacrimal fluid, and the instillation of MH nanoparticles for 14 days did not affect the behavior (balance of secretion and excretion) of the lacrimal fluid in rabbit corneas. Moreover, there was no observable corneal toxicity of MH nanoparticles, and treatment with MH nanoparticles enhanced the intercellular space ratio in the eyes of rats. MH alone did not permeate into the cornea; however, the co-instillation of MH nanoparticles and dissolved TM (nMTFC) enhanced the corneal penetration of TM. In addition, the intraocular pressure (IOP)-reducing effect of nMTFC was significantly higher than those of the TM solution or the co-instillation of MH microparticles and TM. In conclusion, we found that MH nanoparticles enhance the corneal penetration of dissolved TM with no observable corneal stimulation or obstruction of the nasolacrimal duct by the MH nanoparticles. It is possible that the co-instillation of MH nanoparticles may provide a useful way to improve the bioavailability of water-soluble drugs in the ophthalmic field. These findings provide significant information that can be used to design further studies aimed at developing anti-glaucoma eye drugs.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Experimental Eye Research - Volume 165, December 2017, Pages 118-124
Journal: Experimental Eye Research - Volume 165, December 2017, Pages 118-124
نویسندگان
Noriaki Nagai, Fumihiko Ogata, Hiroko Otake, Naohito Kawasaki, Yosuke Nakazawa, Kazutaka Kanai, Norio Okamoto, Yoshikazu Shimomura,