کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5716368 | 1606649 | 2017 | 8 صفحه PDF | دانلود رایگان |
- In patients with IDBC, high HSP10 expression was associated with poor overall survival.
- HSP10 expression was negatively correlated with ER and PR expression.
- HSP10 might be an independent poor prognosis biomarker.
SummaryHeat shock proteins (HSPs) usually are associated with stress response and tolerance. HSP10 is a co-chaperone for HSP60, which is involved in the mitochondrial protein-folding machinery. To the best of our knowledge, the expression of HSP10 in invasive ductal breast carcinoma (IDBC) has never been reported. In the present study, HSP10 expression in 242 cases of IDBC and 46 cases of noncancerous breast tissues was detected by immunohistochemistry staining. High expression was significantly more common in IDBC than in noncancerous breast tissues (PÂ <Â .001). Also, high expression was significantly more common in poorly differentiated than in well- and moderately differentiated IDBC (PÂ =Â .023). Furthermore, high expression correlated negatively with estrogen receptor and progesterone receptor expression (PÂ =Â .031 and PÂ =Â .042, respectively). The most interesting result of the study was that high expression of HSP10 was significantly associated with shorter overall survival by both univariate and multivariate analyses (PÂ =Â .013 and PÂ =Â .036, respectively). In conclusion, we report for the first time that high expression of HSP10 is negatively associated with estrogen receptor/progesterone receptor status and might be a novel independent biomarker for poor prognosis in IDBC.
Journal: Human Pathology - Volume 61, March 2017, Pages 173-180