کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5716385 1606647 2017 13 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Progress in pathologyImmunohistochemical approach for the diagnosis of a liver mass on small biopsy specimens
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی آسیب‌شناسی و فناوری پزشکی
پیش نمایش صفحه اول مقاله
Progress in pathologyImmunohistochemical approach for the diagnosis of a liver mass on small biopsy specimens
چکیده انگلیسی


- HCC shares overlapping histological features with benign hepatocellular lesions.
- Metastatic tumors can be indistinguishable from HCC on histologic grounds.
- IHC markers play an important role in establishing an accurate diagnosis.

SummaryWell-differentiated hepatocellular carcinoma (HCC) shares overlapping histological features with benign hepatocellular lesions, including hepatocellular adenoma and focal nodular hyperplasia in non-cirrhotic liver, and with high-grade dysplastic nodule in cirrhotic liver. Several metastatic tumors, such as neuroendocrine tumor, renal cell carcinoma, adrenocortical carcinoma, melanoma, and epithelioid angiomyolipoma, can be indistinguishable from HCC on histologic grounds. Since this distinction has important therapeutic implications, judicious use of immunohistochemical markers plays an important role in establishing an accurate diagnosis, especially when limited material of tumor is available on cell block or a small core biopsy. This review describes commonly used immunohistochemical markers used in the diagnosis of HCC, highlighting advantages and disadvantages of each marker, and suggests appropriate immunohistochemical panels for specific clinicopathologic situations.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Human Pathology - Volume 63, May 2017, Pages 1-13
نویسندگان
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