Case ReportStromal lipofuscinosis of the seminal vesicle: Incidental finding in two patients treated for prostatic adenocarcinoma by prostatectomy and cryotherapy

Stromal lipofuscinosis of the seminal vesicles has been described in only one prior report as an incidental finding in two patients who underwent prostatectomy for prostatic adenocarcinoma. We report two additional cases of lipofuscinosis occurring in the seminal vesicle stromal cells, identified incidentally in two patients treated for prostatic carcinoma by radical prostatectomy and cryotherapy, respectively. A 50-year-old patient had prostatic carcinoma, Gleason Score 3 + 4 = 7 (Grade group 2) on needle biopsy. At radical prostatectomy, a marked stromal lipofuscinosis was identified in both seminal vesicles, but was not found in the prostatic tissue. The second case was a 74-year-old patient in whom stromal lipofuscinosis was identified in one of the targeted biopsies of the seminal vesicles, as part of the surveillance post-cryotherapy assessment. The patient underwent cryotherapy 36 months previously for prostatic carcinoma, Gleason score 3 + 4 = 7/10 (Grade group 2). The stromal lipofuscinosis seen in the first case was more florid and extensive compared to the focal and more discrete lipofuscinosis, found in the patient treated by cryotherapy. Both patients had no prior history of a malabsorption syndrome, or exposure to a common pharmaceutical agent. Stromal lipofuscinosis represents an extremely rare, incidental and idiopathic finding in patients treated for prostatic carcinoma. This report also documents the first example of stromal lipofuscinosis observed in a post-cryotherapy treatment setting.