کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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5716452 | 1606669 | 2017 | 4 صفحه PDF | دانلود رایگان |
Plasma cell myeloma (PCM) is a neoplasm of plasma cells, end-stage post germinal center B cells, which shows a variable clinical spectrum from asymptomatic to aggressive; the nature of the disease is generally progressive. Rarely, leukemia arises treated plasma cell myeloma. Acute myeloid leukemia/Myelodysplastic syndrome (AML/MDS) is most common, but rare cases of B lymphoblastic leukemia/lymphoma (B-ALL) have been described. The diagnosis of transformation or secondary B-ALL is supported by ancillary studies such as flow cytometry, immunohistochemistry, and molecular studies. Once the diagnosis of a B-ALL is made, consideration should is given as to whether the malignancy is a clonally related transformation of the original PCM or treatment related second leukemia. We present a case of B-ALL after PCM which does not appear to show a clonal relationship with the original PCM suggesting a treatment related B-ALL.
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Journal: Human Pathology: Case Reports - Volume 10, November 2017, Pages 60-63