Computer model predicting breakthrough febrile urinary tract infection in children with primary vesicoureteral reflux

A computational model using multiple variables including bladder volume at onset of VUR provides individualized prediction of children at risk for breakthrough fUTI. A web-based prognostic calculator based on this model will provide a useful tool for assessing personalized risk of breakthrough fUTI in children with primary VUR.Table. Univariate analysis of clinical variables with associated HR of developing breakthrough fUTI. Dilating VUR defined as grades 3-5.VariableHRHR 95% CIpAge0.980.90, 1.070.69Gender (female)2.720.84, 8.770.09Dilating VUR1.601.05, 2.420.03Bilateral VUR1.500.97, 2.300.07BBD1.660.99, 2.750.05History UTI11.720.57, 5.160.34≥22.980.98, 9.030.05History of fUTI2.171.22, 3.850.01VUR onset bladder volume (≤35% PBC)1.741.15, 2.630.01BBD = bladder-bowel dysfunction; fUTI = febrile urinary tract infection; HR = hazard ratio; PBC = predicted bladder capacity; VCUG = voiding cystourethrogram; VUR = vesicoureteral reflux.