| کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
|---|---|---|---|---|
| 5721730 | 1608100 | 2018 | 5 صفحه PDF | دانلود رایگان |
کلمات کلیدی
1.مقدمه
۲. روش
۲.۱. نمونه
۲.۲. معیارها
۲.۲.۱. تشخیص‌ها
۲.۲.۲. بد رفتاری در دوران کودکی
۲.۲.۳. شدت
۲.۳. تحلیل آماری
۲.۴. محاسبه قدرت
۳. نتایج
۳.۱. توصیف نمونه
جدول ۱. نماگرهای شدت جداگانه در نمونه
۳.۲. اختلال اضطرابی، بد رفتاری در دوران کودکی، و شدت اختلال دو قطبی
۳.۳. تحلیل‌های ثانویه
جدول ۲. تاثیر اختلالات اضطرابی روی نماگرهای شدت
۳.۴. تحلیل شدت
جدول ۳. تاثیر بد رفتاری در دوران کودکی روی نماگرهای شدت
۴. بحث
جدول ۴. تاثیر اختلالات اضطرابی جداگانه روی نماگرهای شدت کلی
- Anxiety disorders are associated with unfavourable outcome in bipolar disorder.
- Obsessive compulsive disorder is most strongly associated with adverse outcome.
- Childhood maltreatment is specifically associated with suicide attempts.
BackgroundComorbid anxiety disorders and childhood maltreatment have each been linked with unfavourable outcomes in people with bipolar disorder. Because childhood maltreatment is associated with anxiety disorders in this population, their respective predictive value remains to be determined.MethodsIn 174 adults with bipolar disorder, we assessed childhood maltreatment using the Childhood Trauma Questionnaire and lifetime anxiety disorders with the MINI International Neuropsychiatric Interview. We constructed an overall index of severity of bipolar disorder as a sum of six indicators (unemployment, psychotic symptoms, more than five manic episodes, more than five depressive episodes, suicide attempt, and hospital admission). We tested the relationship between childhood maltreatment, the number of anxiety disorders and the overall severity index using ordered logistic regression.ResultsThe number of lifetime anxiety disorders was associated with the overall severity index (OR = 1.43, 95%CI = 1.01-2.04, p = 0.047). This relationship was only slightly attenuated when controlled for childhood maltreatment (OR = 1.39, 95%CI = 0.97-2.00, p = 0.069). The relationship between childhood maltreatment and the overall severity index was not statistically significant (OR = 1.26, 95%CI = 0.92-1.74, p = 0.151). Secondary analyses revealed that childhood maltreatment was associated with suicide attempts (OR = 1.70, 95%CI = 1.15-2.51, p = 0.008) and obsessive compulsive disorder was associated with the overall severity index (OR = 9.56, 95%CI = 2.20-41.47, p = 0.003).LimitationsThis was a cross-sectional study with a moderate-sized sample recruited from a specialist program.ConclusionsWhile comorbid anxiety disorders are associated with the overall severity of bipolar disorder, childhood maltreatment is specifically associated with suicide attempts. Clinicians should systematically assess both factors. Interventions to improve outcomes of people with bipolar disorder with comorbid anxiety disorders and history of childhood maltreatment are needed.
Journal: Journal of Affective Disorders - Volume 225, 1 January 2018, Pages 337-341