Research paperGender differences in quality of life and functional disability for depression outpatients with or without residual symptoms after acute phase treatment in China

- We model depressed outpatients from eleven hospitals in China.
- Quality of life and functional impairment are predictors of depression remission.
- We examine gender differences with or without residual symptoms after treatment.
- Depression affects men more seriously than women after acute phase treatment.
- Gender differences affect acute treatment, remission and recovery.

BackgroundDepression is associated with substantial personal suffering and reduced quality of life and functioning. The aim of this study was to investigate gender differences on quality of life and functional impairment of outpatients with depression after acute phase treatment.Methods1503 depression outpatients were recruited from eleven hospitals in China. Subjects were evaluated with sociodemographic characteristics, history and self-report instruments, related to severity of symptoms, function and quality of life. All data were analyzed to determine the gender differences.ResultsMen had a younger age at onset and the first onset age, higher education compared to women in total patients and with or without residual symptoms group. Using regression analysis, it was found that gender was significantly statistically related to severity scores of SDS and had no correlation with Q-LES-Q-SF total scores. In the residual symptoms group, greater functional impairment was noted by men in the area of work and social life. Significant gender differences of mood, work and sexual life in quality of life were observed.LimitationsThis is a cross-sectional study of depressed outpatients and duration of acute phase treatment may not an adequate time to measure changes.ConclusionsDepression appears to affect men more seriously than women after acute phase treatment. Men had a younger age at onset and the first onset age, higher education, more functional impairment and lower satisfaction of quality of life in mood, work and sexual life. Gender differences affect acute treatment, remission and recovery.