Research paperDiabetes mellitus is associated with late-onset post-stroke depression

- The predictor of the late onset post-stroke depression remains unclear.
- The acute ischemic stroke patients with diabetes were more easily to suffer late-onset PSD.
- A raised glucose or/and Hbalc should alert one to future onset of depression.

ObjectiveTo explore the associated factors of late-onset post-stroke depression (PSD).MethodsA total of 251 patients with acute ischemic stroke were recruited. The evaluation of depression was performed 2 weeks after ischemia. 206 patients showing no depression in 2 weeks were followed up. They were divided into late-onset PSD group and non-depressed group by clinical interview with Hamilton depression scale score 3 months after stroke. On the first day following hospitalization, the clinical data including age, gender, educational level and vascular risk factors were recorded. The severity, etiological subtype and location of stroke were evaluated. The inflammatory mediators, glucose and lipid levels were recorded on the day of admission. The association between clinical factors and late-onset PSD was explored by logistic regression analysis. The ROC analysis was performed to evaluate the predicting power of the clinical factors.Results187 of 206 patients completed the assessment 3 months after stroke. 19 (10.16%) patients were diagnosed as late onset PSD. Diabetes mellitus was an independent risk factor for late-onset PSD (OR 2.675, p = 0.047). ROC analysis demonstrated that glucose and HbA1C could predict late-onset PSD with specificity of 84.4%.LimitationsThe sample of our study was small. The results should be further confirmed in a larger cohort of patients with acute ischemic stroke.ConclusionsThe acute ischemic stroke patients with diabetes mellitus were more tendered to suffer late-onset PSD.