Research paperThe association between well-being and the COMT gene: Dispositional gratitude and forgiveness as mediators

- We found that individuals with the smaller number of the Met alleles reported greater well-being, less depressive symptoms, and greater tendencies for gratitude and forgiveness.
- We found that dispositional gratitude and forgiveness mediated the genotype effects on well-being and depressive symptoms.
- This study demonstrates the contribution of the COMT gene to well-being, dispositional gratitude, and dispositional forgiveness, highlights the importance of gratitude and forgiveness in the relationship between the gene and well-being, and suggests a psychobiological pathway for well-being and depression.

BackroundPrevious studies have demonstrated the contributions of genetic variants and positive psychological traits (e.g. gratitude and forgiveness) to well-being. However, little is known about how genes interact with positive traits to affect well-being.MethodsTo investigate to what extent the COMT Val158Met polymorphism modulates well-being and to what extent dispositional gratitude and forgiveness mediate the individual differences in well-being, 445 participants were recruited and required to complete a battery of questionnaires.ResultsWe found that individuals with a smaller number of the Met alleles reported greater well-being, less depressive symptoms, and greater tendencies for gratitude and forgiveness. Moreover, dispositional gratitude and forgiveness mediated the genotype effects on well-being and depressive symptoms. These results remained significant after controlling for non-genetic factors (socioeconomic status, religious beliefs, romantic relationship status, parenting style).LimitationThe sample size limits the generalizability of results.ConclusionThis study demonstrates the contribution of the COMT Val158Met polymorphism to individual differences in well-being and suggests a potential psychobiological pathway from dopaminergic and noradrenergic systems to happiness.