Alterations in the brainstem volume of patients with major depressive disorder and their relationship with antidepressant treatment

- We investigate the volume changes of brainstem regions in MDD using the FreeSurfer.
- Medulla oblongata, pons, midbrain, and superior cerebellar peduncle were included.
- Drug-naïve patients had greater brainstem volumes compared to healthy controls.
- Remitted patients had reduced pons and midbrain volumes compared to healthy controls.

BackgroundMorphologic changes of the brainstem in major depressive disorder (MDD) have rarely been reported in neuroimaging studies, even though, monoaminergic neurotransmitters are synthesized in several brainstem regions. We aimed to investigate volume changes in each region of the brainstem and their association with antidepressant use or the remission status of MDD.MethodsA total of 126 patients with MDD and 101 healthy controls underwent T1-weighted structural magnetic resonance imaging. We analyzed volumes of each brainstem region, including the medulla oblongata, pons, midbrain, and superior cerebellar peduncle, and the volume of the whole brainstem using the FreeSurfer.ResultsThe patients with MDD had significantly greater midbrain volumes (P=0.013) compared to healthy controls. In particular, drug-naïve patients with MDD had significantly greater brainstem volumes compared to healthy controls (P=0.007), while no significant findings were observed between the antidepressant treatment group and healthy controls. The remitted patient group had reduced pons (P=0.002) and midbrain (P=0.005) volumes compared to healthy controls, while the non-remitted MDD patient group had significantly greater midbrain volumes compared to the healthy controls (P=0.017).LimitationsWe could not distinguish gray versus white matter volumes changes in our analysis.ConclusionsWe observed that the midbrain is enlarged in patients with a current depressive episode, who are not undergoing antidepressant treatment. This volume then returns to normal after antidepressant treatment, and is even reduced, when the patient is in remission. Further studies are needed to confirm our observations.