Research paperCognitive behavioral therapy is effective in misophonia: An open trial

- Misophonia is a new psychiatric condition, for which there is currently no evidence-based treatment.
- In our cognitive behavioral therapy (CBT) protocol we combined four techniques.
- CBT was effective in half of the 90 patients.
- Symptom severity and presence of disgust were positive predictors of treatment response.

BackgroundMisophonia is a psychiatric disorder in which ordinary human sounds like smacking or chewing provoke intense anger and disgust. Despite the high burden of this condition, to date there is no evidence-based treatment available. In this study we evaluated the efficacy of cognitive behavioral therapy (CBT) and investigated whether clinical or demographic characteristics predicted treatment response.MethodsNinety patients with misophonia received eight bi-weekly group CBT sessions. Treatment response was defined as a Clinical Global Impression - Improvement Scale (CGI-I) score at endpoint of 1 or 2 (very much or much improved) and a 30% or greater reduction on the Amsterdam Misophonia Scale (A-MISO-S), a measure of the severity of misophonia symptoms.ResultsFollowing treatment 48% (N=42) of the patients showed a significant reduction of misophonia symptoms. Severity of misophonia and the presence of disgust were positive predictors of treatment response.LimitationsThe A-MISO-S is not a validated scale. Furthermore, this was an open-label study with a waiting list control condition.ConclusionsThis is the first treatment study for misophonia. Our results suggest that CBT is effective in half of the patients.