کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5722877 1608907 2017 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
ReviewThe biological and clinical basis for the use of adipose-derived stem cells in the field of wound healing
ترجمه فارسی عنوان
بررسی مبانی بیولوژیکی و بالینی برای استفاده از سلول های بنیادی حاصل از چربی در زمینه بهبود زخم
کلمات کلیدی
داروهای احیا کننده، مهندسی بافت، سلول های بنیادی حاصل از چربی، التیام زخم،
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی سیاست های بهداشت و سلامت عمومی
چکیده انگلیسی


- Worldwide, hard-to-heal wounds are a matter of economic and public concern.
- The emerging fields of regenerative medicine and stem cell-based therapies hold great promise for wound healing.
- ASCs can potentially give the support necessary for recovery of hard-to-heal wounds.
- ASCs can be easily harvested from adipose tissue by means of standard wet liposuction technique.
- ASCs have been widely studied in vitro and in vivo to demonstrate their potential and safety.

Worldwide, hard-to-heal lower limb wounds are estimated to affect 1.5-3% of the adult population with a treatment-related annual cost of $10 billion. Thus, chronic skin ulcers of the lower limb are a matter of economic and public concern. Over the years, multiple medical and surgical approaches have been proposed but they are still inadequate, and no effective therapy yet exists. Regenerative medicine and stem cell-based therapies hold great promise for wound healing. Recently, many plastic surgeons have studied the potential clinical application of adipose-derived stem cells (ASCs), which are a readily available adult stem cell population that can undergo multilineage differentiation and secrete growth factors that can enhance wound-healing processes by promoting angiogenesis, and hence increase local blood supply. ASCs have been widely studied in vitro and in vivo in animal models. However, there are few randomized clinical trials on humans, and these are still ongoing or recruiting patients. Moreover, there is no consensus on a common isolation protocol that is clinically feasible and which would ensure reproducible results. The authors aim to provide readers with an overview of the biological properties of ASCs as well as their clinical application, to help better understanding of present and future strategies for the treatment of hard-to-heal wounds by means of stem cell-based therapies.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Annals of Medicine and Surgery - Volume 20, August 2017, Pages 41-48
نویسندگان
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