کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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5724637 | 1411503 | 2017 | 8 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Original ArticleUse of hyperpolarized helium-3 MRI to assess response to ivacaftor treatment in patients with cystic fibrosis Original ArticleUse of hyperpolarized helium-3 MRI to assess response to ivacaftor treatment in patients with cystic fibrosis](/preview/png/5724637.png)
BackgroundThis pilot study evaluated the effect of short- and long-term ivacaftor treatment on hyperpolarized 3He-magnetic resonance imaging (MRI)-defined ventilation defects in patients with cystic fibrosis aged â¥Â 12 years with a G551D-CFTR mutation.MethodsPart A (single-blind) comprised 4 weeks of ivacaftor treatment; Part B (open-label) comprised 48 weeks of treatment. The primary outcome was change from baseline in total ventilation defect (TVD; total defect volume:total lung volume ratio).ResultsMean change in TVD ranged from â 8.2% (p = 0.0547) to â 12.8% (p = 0.0078) in Part A (n = 8) and â 6.3% (p = 0.1953) to â 9.0% (p = 0.0547) in Part B (n = 8) as assessed by human reader and computer algorithm, respectively.ConclusionsTVD responded to ivacaftor therapy. 3He-MRI provides an individual quantification of disease burden that may be able to detect aspects of the disease missed by population-based spirometry metrics. Assessments by human reader and computer algorithm exhibit similar trends, but the latter appears more sensitive.www.clinicaltrials.gov identifier: NCT01161537
Journal: Journal of Cystic Fibrosis - Volume 16, Issue 2, March 2017, Pages 267-274