Recent Advances in TransplantationRenal transplantationIncidence of Diabetes Mellitus After Kidney Transplantation in Slovakia: Multicentric, Prospective Analysis

- The incidence of PTDM in the Slovak Republic in 2014 was 38.3%.
- The age at the time of KT, the value of BMI at the time of KT, and the value of insulin resistance index at the time of KT are predictive factors of PTDM.
- The independent risk factors of PTDM are age at the time of KT of more than 60 years, waist circumference at the time of KT in men more than 94 cm and in women more than 80 cm, BMI at the time of KT, and triacylglycerols at the time of KT more than 1.7 mmol/L.
- The dominating risk factor for PTDM development is insulin resistance prior to KT.

BackgroundThe incidence rate of post-transplant diabetes mellitus (PTDM) after kidney transplantation (KT) is 5% to 40%. The objective of this analysis was to identify the risk factors of PTDM after KT in the Slovak Republic (SR).MethodsIn the group of 133 patients/non-diabetics, we identified the risk factors of PTDM in the monitored period of 12 months from transplantation.ResultsThe incidence of PTDM in the SR in 2014 was 38.3%. By logistic regression, we discovered that the age at the time of KT [odds ratio, 1.0885; 95% CI, 1.0222-1.1592; P = .0082], the value of body mass index (BMI) at the time of KT [odds ratio, 1.4606; 95% CI, 1.0099-2.1125; P = .0442], and the value of insulin resistance index (homeostatic model assessment for insulin resistance) at the time of KT [odds ratio, 2.5183; 95% CI, 1.7119-3.4692; P < .0001] represented predictive factors of PTDM. The independent risk factors of PTDM in our group were age at the time of KT of more than 60 years [HR 0.3871; 95% CI 0.1659-1.7767; P = .0281], waist circumference at the time of KT in men more than 94 cm and in women more than 80 cm [HR, 3.4833; 95% CI, 1.2789-9.4878 (P = .0146)], BMI at the time of KT [HR 3.0011; 95% CI 1.0725-8.3977 (P = .0363)], and triacylglycerols at the time of KT more than 1.7 mmol/L [HR, 2.9763; 95% CI, 1.0141-8.7352; P = .0471].ConclusionsIn the group of Slovak patients after kidney transplantation, the dominating risk factor for PTDM development was insulin resistance prior to KT.