کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5729151 | 1411676 | 2016 | 4 صفحه PDF | دانلود رایگان |
- CD4+ T cell iATP level was detected using the Cylex Immuknow Assay method, and analyzed retrospectively according to immunosuppressive therapy protocol.
- There is a relationship between distribution immunosuppressive therapy protocol and CD4+ T cell iATP level after liver transplantation.
- MMF and Rapa lower the CD4+ T cell iATP level significantly.
ObjectiveThe aim of this work was to analyze the correlation between immunosuppressive therapy and CD4+ T-cell intracellular adenosine triphosphate (iATP) levels after liver transplantation and to describe the distribution characteristics of iATP in CD4+ T cells among liver transplant recipients.MethodsWe studied 172 patients who were followed regularly after liver transplantation with long-term stable conditions from July 2010 to October 2012. CD4+ T-cell iATP levels were detected with the use of the Cylex Immuknow Assay method and analyzed retrospectively according to immunosuppressive therapy protocol.ResultsThere was a significant difference in CD4+ T-cell iATP level among the recipients receiving different immunosuppressive therapy protocols after liver transplantation. CD4+ T-cell iATP level in the FK506 group and FK506Â + prednisone (Pred) groups was higher than in the FK506Â + mycophenolate mofetil (MMF), FK506Â + MMFÂ + Pred, and rapamycin (Rapa) groups. CD4+ T-cell iATP level in patients receiving an MMF protocol was lower than in the group without MMF.ConclusionsThere is a relationship between distribution immunosuppressive therapy protocol and CD4+ T-cell iATP level after liver transplantation. MMF and Rapa lower the CD4+ T-cell iATP level significantly.
Journal: Transplantation Proceedings - Volume 48, Issue 6, JulyâAugust 2016, Pages 2094-2097