Current Topics in TransplantationRenal transplantationPartners in Crime: Kidney Transplantation and Seizure Disorder

- Kidney transplantation negatively affects the care of seizure disorders in terms of mortality, length of stay, cost of care, and risk of complications.
- A history of seizure disorder negatively affects an admission for kidney transplantation procedure in terms of costs of care and risk of postoperative complications.
- Better awareness, clinical trials, and practice guidelines are needed given the disease-specific adverse relationship between kidney transplantation and seizure disorder.

Seizure disorder is a common neurologic complication of kidney transplantation and often presents as a complex management challenge. Little is known about the risks mutually conferred by the 2 clinical entities and the effects of such risks on clinical outcomes. Using the National Inpatient Sample, our goal was to examine the effects of kidney transplantation and seizure disorder on mortality, hospitalization statistics, clinical complications, and cost of care. A history of kidney transplantation was shown to negatively affect the care of seizure disorder, and a history of seizure disorder also negatively affected the clinical outcomes of kidney transplantation. Our findings are important for initiating discussions and prompting future studies to further examine disease-specific risks of kidney transplantation.