کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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5729289 | 1411679 | 2017 | 4 صفحه PDF | دانلود رایگان |
BackgroundTransplant kidney function is thought to be affected by sex differences, such as physical conditions including muscle volume, sex hormones, immune responses, and so forth. We examined the effect of sex differences on transplant kidney function.MethodsThe subjects were selected from kidney transplant recipients, who received kidney transplantation on our hospital between January 2000 and August 2015. Cadaveric donors and parent-child pairs with an age difference were excluded, then we included 47 recipients whose sex was different from the sex of the donor. We compared transplant kidney function between male donors and female recipients group (MâF, n = 20) and female donors and male recipients group (FâM, n = 27).ResultsNadir creatinine value was higher in the FâM group than in the MâF group (1.09 mg/dL vs 0.76 mg/dL, P < .0001). The estimated glomerular filtration rate (eGFR) was significantly higher in the MâF group than in the FâM group (66.6 mL/min/1.73 m2 vs 50.1 mL/min/1.73 m2, P = .002), and eGFR ratio (recipient to donor) was significantly higher in the MâF group than in the FâM group (1.13 vs 0.57, P < .0001). Multiple linear regression analysis showed that the only the sex of the recipient was significant prognostic factor of eGFR after renal transplantation (P = .037).ConclusionsThe short-term kidney function of the graft from male to female was better than that of the graft from female to male.
Journal: Transplantation Proceedings - Volume 49, Issue 1, JanuaryâFebruary 2017, Pages 61-64