کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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5731205 | 1611466 | 2017 | 5 صفحه PDF | دانلود رایگان |
BackgroundSingle-session intraoperative radiation therapy (IORT) minimizes treatment demands associated with traditional whole breast radiation therapy (WBRT) but outcomes on local disease control and morbidity among the elderly is limited.MethodsA multi-institutional retrospective registry was established from 19 centers utilizing IORT from 2007 to 2013. Patient, tumor, and treatment variables were analyzed for ages <70 and â¥70.ResultsWe evaluated 686 patients (<70 = 424; â¥70 = 262) who were margin and lymph node negative. Patients <70 were more likely to have longer operative time, oncoplastic closure, higher rates of IORT used as planned boost, and receive chemotherapy and post-operative WBRT. Wound complication rates were low and not significantly different between age groups. Median follow-up was 1.06 (range 0.51-1.9) years for < 70 and 1.01 (range 0.5-1.68) years for â¥Â 70. There were 5 (0.73%) breast recurrences (4 in <70 and 1 â¥Â 70, p = 0.65) and no axillary recurrences during follow-up.ConclusionsIORT was associated with a low rate of wound complication and local recurrence on short-term follow-up in this cohort.
Journal: The American Journal of Surgery - Volume 214, Issue 4, October 2017, Pages 629-633