کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5731615 1611885 2016 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Original articleIschemic preconditioning in hepatic ischemic-reperfusion injury
ترجمه فارسی عنوان
مقاله اصلی پیشگیری از پیش آگهی در آسیب های ایسکمیک و رپرفیوژن کبدی
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی عمل جراحی
چکیده انگلیسی

Background/IntroductionIschemic preconditioning is a method in which brief periods of ischemia render tissues resistant to injury resulting from prolonged ischemia and reperfusion, so-called ischemia-reperfusion injury.PurposeTo elucidate the possible protective role of ischemic preconditioning in rat livers with ischemia-reperfusion injury.MethodsRats were first allocated to either a sham control or an ischemic preconditioning group. On the following day, the rats from each group were administered either 30 minutes or 45 minutes hepatic ischemia. Next, rat livers were harvested for measuring proliferating cell nuclear antigen, heme oxygenase-1, inducible nitric oxide synthase, and heat shock protein 70 mRNA levels.ResultsBoth proliferating cell nuclear antigen and hemeoxygenase-1 expression increased significantly after 45 minutes hepatic ischemia compared with those after 30 minutes hepatic ischemia, but they decreased significantly with ischemic preconditioning. However, ischemic preconditioning did not affect inducible nitric oxide synthase or heat shock protein 70 expression.ConclusionFrom the preliminary findings, further elucidation is warranted.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Formosan Journal of Surgery - Volume 49, Issue 5, October 2016, Pages 169-173
نویسندگان
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