کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5731752 1611936 2017 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Original ResearchSignificance of the Glasgow Prognostic Score for patients with colorectal liver metastasis
ترجمه فارسی عنوان
تحقیقات اصلی ارزش پیشآگهی گلاسکو برای بیماران مبتلا به متاستاز کبدی کولورکتال
کلمات کلیدی
متاستاز کبدی کولورکتال، جراحی کبد، نمره پیش آگهی گلاسگو، نمره پیش آگهی مبتنی بر التهاب، بیومارکر،
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی عمل جراحی
چکیده انگلیسی


- GPS is an important predictor of recurrence following liver resection in patients with CRLM.
- GPS isn't a predictor of survival following liver resection in patients with CRLM.
- We have created a new index that can select patients with poorer prognosis using degree of histologic differentiation, CEA level and GPS.

BackgroundSystemic inflammation and nutritional status are strongly associated with tumor progression. Inflammation-based prognostic scores, such as the Glasgow Prognostic Score (GPS), reflect these states and are predictive in patients with several types of advanced cancers. The aim of this study was to evaluate the significance of GPS in patients with colorectal liver metastasis (CRLM).Patients and methodsStudy subjects were 134 patients with CRLM who underwent initial radical liver resection at Hiroshima University Hospital between January 2000 and December 2013. Univariate and multivariate analyses were performed to identify variables associated with overall and recurrence-free survival following liver resection in two groups based on GPS.ResultsThere was no significant relationship between overall survival and GPS. Recurrence-free survival was significantly poorer in patients with GPS 1-2 than in those with GPS 0 (p < 0.01). In multivariate analysis for recurrence-free survival, moderate histologic differentiation, carcinoembryonic antigen level ≥10 ng/mL, and GPS 1-2 were identified as independent prognostic factors.ConclusionWe suggest that GPS is an important predictor of recurrence following liver resection in patients with CRLM, and it should be considered one of the evaluation criteria for liver resection.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: International Journal of Surgery - Volume 42, June 2017, Pages 209-214
نویسندگان
, , , , , , , , , , , , ,