کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5732774 1612075 2017 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Case reportMixed adenoneuroendocrine carcinoma of the distal bile duct: A case report
ترجمه فارسی عنوان
گزارش مورد: کارسینوم آدنومروئیدوکرینیک مجرای صفراوی دیستال: گزارش موردی
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی عمل جراحی
چکیده انگلیسی


- Mixed adenoneuroendocrine carcinomas (MANECs) of the distal bile duct are extremely rare.
- The treatment of MANECs of the bile duct remains controversial and the prognosis is poor.
- Larger studies are required to establish standard treatment regimens of MANECs of the bile duct.

IntroductionMixed adenoneuroendocrine carcinomas (MANECs) of the distal bile duct are extremely rare, and only a few cases have been reported in the English literature.Presentation of caseAn 82-year-old man was referred to our hospital for increasing biliary enzymes. Abdominal computed tomography (CT) showed enlargement of the intrahepatic bile ducts and stenosis of the distal bile duct. Endoscopic retrograde cholangiopancreatography showed stenosis of the distal bile duct and a high-density signal at the same site on diffusion weighted imaging. PET-CT showed increased FDG accumulation (SUVmax: 4.5) at the distal bile duct stenosis. Biopsy specimens obtained by endoscopic ultrasonography-guided fine-needle aspiration revealed adenocarcinoma. The patient was diagnosed with adenocarcinoma of the distal bile duct and underwent subtotal stomach-preserving pancreaticoduodenectomy with regional lymph node dissection. The resected distal bile duct tumor was 18 × 14 × 12 mm in diameter. Hematoxylin and eosin staining revealed a composite carcinoma with adenocarcinoma and non-adenocarcinoma elements. The non-adenocarcinoma component stained positive for synaptophysin and chromogranin A. The Ki-67 labeling index was 37%. The non-adenocarcinoma component was therefore diagnosed as a neuroendocrine carcinoma. The two composite carcinoma was diagnosed as MANEC of the distal bile duct. The patient was treated with surgery alone and he remained disease-free for 7 months after the surgery.DiscussionThe treatment of MANECs of the bile duct remains controversial and the prognosis is poor.ConclusionsThere is no standard treatment for MANECs of the bile duct. Larger studies are required to establish standard treatment regimens.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: International Journal of Surgery Case Reports - Volume 39, 2017, Pages 203-207
نویسندگان
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