کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5733688 1612516 2017 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Personalized treatment in patients with colorectal liver metastases
ترجمه فارسی عنوان
درمان شخصی در بیماران مبتلا به متاستاز کبدی کولورکتال
کلمات کلیدی
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی عمل جراحی
چکیده انگلیسی

BackgroundPrecision Medicine Initiative is a new research effort aiming to offer personalized treatment in many diseases, including cancer. The aim of the present article is to offer novel insights about the role of personalized treatment in patients with colorectal liver metastases (CRLM).MethodsA review of the literature regarding personalized medicine and colorectal liver metastases was performed mainly in the MEDLINE/PubMed database.ResultsSurgical resection remains the only hope for cure of CRLM. Improved surgical strategies to optimize remnant liver volume are recently introduced and gaining ground. Following resection of CRLM scoring systems have been developed by combining certain preoperative factors such as microsatellite instability KRAS expression and sensitivity to immunotherapy with Programmed Death-1 inhibitor.ConclusionsMultidisciplinary management of patients with CRLM has markedly contributed to increased survival. While the last several decades have been characterized by these important developments, future advances for patients with CRLM will depend on a better understanding of genomics and molecular biology to facilitate characterization of a specific tumor “identity” so that individualized treatment for each CRLM patient becomes the rule, and not the exception.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Surgical Research - Volume 216, August 2017, Pages 26-29
نویسندگان
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